Page 42 - Demo

Centella Asiatica%u2019dan T%u00fcretilen Stabil ve Da%u011f%u0131labilir Ekzosomlar%u0131n Safla%u015ft%u0131r%u0131lmas%u0131 ve Kozmetik Kompozisyonlarda Kullan%u0131m%u0131Purification of Stable and Dispersible Exosomes Derived from Centella Asiatica and Their Use in Cosmetic Compositions%u201cEkzosomlar%u201d %u00e7e%u015fitli h%u00fccreler taraf%u0131ndan salg%u0131lanan zar yap%u0131s%u0131na sahip k%u00fc%u00e7%u00fck vezik%u00fclleri ifade etmektedir ve bir t%u00fcr ekstrasel%u00fcler vezik%u00fcl (EV) olarak tan%u0131mlanmaktad%u0131r. T%u00fcm h%u00fccreler, ekstrasel%u00fcler vezik%u00fcller salg%u0131layarak di%u011fer h%u00fccrelerle veya d%u0131%u015f ortamla bilgi al%u0131%u015fveri%u015finde bulunmaktad%u0131rlar. Ekzosomlar yakla%u015f%u0131k 50-200 nm boyutundad%u0131rlar ve proteinler, lipitler ve n%u00fckleik asitler gibi fizyolojik olarak aktif maddeler i%u00e7ermektedirler.Ekzosomlar memeliler, bakteriler ve bitkiler de dahil olmak %u00fczere %u00e7e%u015fitli h%u00fccrelerde bulunmaktad%u0131rlar ve k%u00f6ken h%u00fccrenin durumunu yans%u0131tmaktad%u0131rlar, bu da onlar%u0131 te%u015fhis ve tedavi i%u00e7in yararl%u0131 hale getirmektedir. Ekzosomlar, kolay h%u00fccre i%u00e7i penetrasyon olana%u011f%u0131 sa%u011flayan ve %u00e7e%u015fitli fizyolojik ve patolojik i%u015flevleri yerine getiren %u00e7ift katmanl%u0131 fosfolipid membran yap%u0131lard%u0131r.%u201cExosomes%u201d refer to small vesicles with a membrane structure secreted by various cells and are defined as a type of extracellular vesicle (EV). All cells exchange information with other cells or external environments, secreting extracellular vesicles. Exosomes are approximately 50-200 nm in size and contain physiologically active substances such as proteins, lipids, and nucleic acids.Exosomes exist in diverse cells, including those of mammals, bacteria, and plants, and reflect the state of the originating cell, making them useful for diagnostics and treatment. Exosomes are doublelayered phospholipid membrane structures, facilitating easy intracellular penetration and carrying out various physiological and pathological functions. Makale / Article40Yuto Tsutsui Gonca Tuncer Filiz SevimliYa%u015fam Bilimleri %u0130%u015f Birimi Y%u00f6neticisiBusiness Unit Manager Life SciencesEigenmann & VeronelliGlobal %u0130%u015f Birimi Y%u00f6neticisi - Ki%u015fisel Bak%u0131mGlobal Business Unit Manager - Personal CareGSIEsans %u00dcr%u00fcn M%u00fcd%u00fcr%u00fcProduct Manager FragrancesEigenmann & VeronelliDerleme ve %u00c7eviri / Compilation and Translation