Page 45 - Demo

Makale / Article43mu ile muamele edilen h%u00fccreler, kontrol ile kar%u015f%u0131la%u015ft%u0131r%u0131ld%u0131%u011f%u0131nda MMP1 mRNA ekspresyonunu azaltm%u0131%u015ft%u0131r, ekstrakt ile kar%u015f%u0131la%u015ft%u0131r%u0131ld%u0131%u011f%u0131nda k%u0131r%u0131%u015f%u0131kl%u0131k iyile%u015ftirmede etkinli%u011finin daha fazla oldu%u011funu do%u011frulam%u0131%u015ft%u0131r. 1x107 par%u00e7ac%u0131k/ml Cica ekzosomu ile muamele, MMP1%u2019in mRNA ekspresyonunu azaltt%u0131%u011f%u0131 kan%u0131tlanm%u0131%u015f olan TGF%u03b21%u2019den daha y%u00fcksek etkinlik g%u00f6stermi%u015ftir (%u015eekil 3).the control, confirming its higher efficacy in wrinkle improvement compared to extract. The treatment with 1x107 particles/ml of Cica exosome also showed higher efficacy than TGF%u03b21, which is proven to downregulate the mRNA expression of MMP1 (Figure 3).Centella Asiatica ekzosomlar%u0131n%u0131n h%u00fccre rejenerasyonu etkinli%u011finin do%u011frulanmas%u0131: Yara iyile%u015fmesiCica, yenileyici etkileri ile bilinmektedir. H%u00fccre rejenerasyonunda Cica ekzosomunun etkinli%u011fini de%u011ferlendirmek i%u00e7in bir yara iyile%u015ftirme %u00e7al%u0131%u015fmas%u0131 yap%u0131lm%u0131%u015ft%u0131r. Bu deneyde, bir %u00e7izik yap%u0131lm%u0131%u015ft%u0131r, yara iyile%u015ftirme aktivitelerini kar%u015f%u0131la%u015ft%u0131rmak i%u00e7in de%u011fi%u015fen konsantrasyonlarda Cica ekstrakt%u0131, Cca ekzosomu veya %0.1 madekasosit ile h%u00fccreler muamele edilmi%u015flerdir. Kontrole k%u0131yasla hem Cica ekstrakt%u0131 hem de ekzosom %u00f6nemli %u00f6l%u00e7%u00fcde daha y%u00fcksek h%u00fccre rejenerasyonu etkileri g%u00f6stermi%u015ftir, burada Cica ekzosomu daha da y%u00fcksek rejenerasyon sa%u011flam%u0131%u015ft%u0131r. 1x107 par%u00e7ac%u0131k/ml Cica ekzosomu ile yap%u0131lan muamele, %u00f6nemli yara iyile%u015ftirme aktivitesi kan%u0131tlanm%u0131%u015f olan madekasositten bile daha y%u00fcksek etkinlik g%u00f6stermi%u015ftir (%u015eekil 4).Confirmation of cell regeneration efficacy of Centella Asiatica exosomes: Wound healingCica is known for its regenerative effects. A wound healing assay was done to evaluate the efficacy of Cica exosome in cell regeneration. In this experiment, a scratch was performed, and the cells were treated with varying concentration of Cica extract, Cca exosome, or 0.1% madecassoside to compare their wound-healing activity. Both Cica extract and exosome showed significantly higher cell regeneration effects compared to the control, in which Cica exosome exhibited even higher regeneration. The treatment with 1x107 particles/ml of Cica exosome even showed higher efficacy than Madecassoside, which is proven for its significant wound-healing activity (Figure 4).