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Makale / Article44Centella Asiatica ekzosomlar%u0131n%u0131n cilt iyile%u015ftirme etkinli%u011finin do%u011frulanmas%u0131: Yara iyile%u015fmesiAyr%u0131ca, Cica ekzosomlar%u0131n%u0131n cilt parlakl%u0131%u011f%u0131, cilt nemi, cilt esnekli%u011fi ve cilt yo%u011funlu%u011fu etkilerini de%u011ferlendirmek i%u00e7in in vivo testler de yap%u0131lm%u0131%u015ft%u0131r. %u0130nsanlar %u00fczerinde uygulama testi, 20 ila 60 ya%u015flar%u0131 aras%u0131ndaki 23 yeti%u015fkin kad%u0131n %u00fczerinde, %5 Cica ekzosomu i%u00e7eren ampullerden olu%u015fan test %u00fcr%u00fcn%u00fcyle ger%u00e7ekle%u015ftirilmi%u015ftir. Cilt parlakl%u0131%u011f%u0131 ve nemlendirme etkileri kullan%u0131mdan %u00f6nce ve hemen sonra kar%u015f%u0131la%u015ft%u0131r%u0131l%u0131rken, cilt esnekli%u011fi ve cilt yo%u011funlu%u011fu etkileri %u00fcr%u00fcn%u00fc g%u00fcnde iki kez uygulayarak 2 haftal%u0131k kullan%u0131mdan %u00f6nce ve sonra kar%u015f%u0131la%u015ft%u0131r%u0131lm%u0131%u015ft%u0131r. Sonu%u00e7lar, sadece bir kez uygulamadan sonra cilt parlakl%u0131%u011f%u0131nda ve nemlendirmede bir iyile%u015fme g%u00f6stermi%u015ftir ve 2 haftal%u0131k kullan%u0131mdan sonra cilt esnekli%u011finde ve yo%u011funlu%u011funda %u00f6nemli bir iyile%u015fme g%u00f6stererek cilt sa%u011fl%u0131%u011f%u0131n%u0131 iyile%u015ftirmedeki etkinliklerini kan%u0131tlam%u0131%u015ft%u0131r (%u015eekil 5).Confirmation of skin improvement efficacy of Centella Asiatica exosomes: Wound healingIn vivo tests have also been done to evaluate the skin radiance, skin moisture, skin elasticity, and skin density effects of Cica exosomes. The human application test was conducted on 23 adult women aged between 20 to 60, with the test product of ampules containing 5% of Cica exosomes. Skin radiance and moisturizing effects were compared before and immediately after use, while the skin elasticity and skin density effects were compared before and after 2 weeks of usage by applying the product twice a day. The results showed an improvement in skin radiance and moisturization after just one time application and demonstrated a significant improvement in skin elasticity and density after 2 weeks of use, proving their efficacy in improving skin health (Figure 5).