Page 24 - Demo

22 Eyl%u00fcl - September / Ekim - October 2024 mekanik esnekli%u011fi ve biyouyumlulu%u011fu, ciltle uyumlu ve konforlu bir uygulama y%u00fczeyi sa%u011flar. Elektrospinning teknolojisinin transdermal bant %u00fcretimindeki rol%u00fc, bu bantlar%u0131n etkinli%u011fini ve g%u00fcvenli%u011fini art%u0131rma a%u00e7%u0131s%u0131ndan kritik %u00f6neme sahiptir. %u00c7al%u0131%u015fmam%u0131zda C ve E vitamin y%u00fckl%u00fc PU nanoteknolojik transdermal bant, elektrospinning teknolojisi ile elde edilmi%u015ftir. Transdermal bantlar%u0131n Alan Emisyon Tabancal%u0131 Taramal%u0131 Elektron Mikroskobu (FEGSEM) g%u00f6r%u00fcnt%u00fcleri %u00e7ekilmi%u015ftir. Deri alt%u0131 uygulamalara y%u00f6nelik nanoteknolojik trandermal bantlar %u00fcretilmi%u015ftir.Materyal ve Metot%u00c7al%u0131%u015fmam%u0131zda C ve E vitamini patentli bitkisel ekstraktlardan s%u00fcperkritik ekstraksiyon tekni%u011fi ile elde edilmi%u015ftir. S%u00fcperkritik Ekstraksiyon Tekni%u011fi %u0130le C ve E Vitamini %u00dcretimiS%u00fcperkritik ekstraksiyon tekni%u011fi, bitkisel ve organik bile%u015fenlerin ayr%u0131%u015ft%u0131r%u0131lmas%u0131nda kullan%u0131lan modern bir y%u00f6ntemdir. Bu teknik, %u00f6zellikle C ve E vitaminlerinin y%u00fcksek safl%u0131kta ve verimli bir %u015fekilde elde edilmesinde tercih edilmektedir. S%u00fcperkritik ekstraksiyon, s%u0131v%u0131n%u0131n hem gaz hem de s%u0131v%u0131 %u00f6zelliklerini ta%u015f%u0131d%u0131%u011f%u0131 s%u00fcperkritik fazda ger%u00e7ekle%u015fir. Bu y%u00f6ntem, %u00f6zellikle hassas bile%u015fenlerin %u00fcretiminde etkin bir %u00e7%u00f6z%u00fcm sunar.S%u00fcperkritik ekstraksiyon, s%u0131v%u0131n%u0131n s%u00fcperkritik fazda kullan%u0131ld%u0131%u011f%u0131 bir ayr%u0131%u015ft%u0131rma tekni%u011fidir. S%u00fcperkritik faz, belirli bir s%u0131cakl%u0131k ve bas%u0131n%u00e7 alt%u0131nda, bir s%u0131v%u0131n%u0131n hem s%u0131v%u0131 hem de gaz %u00f6zelliklerini ta%u015f%u0131d%u0131%u011f%u0131 bir durumu ifade etmektedir. Bu fazda, s%u0131v%u0131n%u0131n %u00e7%u00f6zme kapasitesi b%u00fcy%u00fck %u00f6l%u00e7%u00fcde artar ve bu da organik bile%u015fenlerin, %u00f6zellikle de vitaminlerin, daha etkili bir %u015fekilde ayr%u0131%u015ft%u0131r%u0131lmas%u0131n%u0131 sa%u011flamaktad%u0131r. S%u00fcperkritik ekstraksiyonda genellikle karbon dioksit (CO%u2082) kullan%u0131l%u0131r, %u00e7%u00fcnk%u00fc bu madde %u00e7evre dostu bir %u00e7%u00f6z%u00fcc%u00fc olarak bilinir ve %u00e7o%u011fu vitaminle uyumludur. Karbon dioksidin s%u00fcperkritik faz%u0131, y%u00fcksek %u00e7%u00f6zme kapasitesine sahiptir ve bu, C ve E vitaminlerinin y%u00fcksek safl%u0131kta elde edilmesini sa%u011flamaktad%u0131r.C vitamini (askorbik asit), suda %u00e7%u00f6z%u00fcn%u00fcr bir vitamin olup g%u00fc%u00e7l%u00fc bir antioksidand%u0131r. V%u00fccutta ba%u011f%u0131%u015f%u0131kl%u0131k sistemini destekler, cilt sa%u011fl%u0131%u011f%u0131n%u0131 iyile%u015ftirir ve demir emilimini art%u0131r%u0131r. E vitamini (tokoferol ve tokotrienoller) ise ya%u011fda %u00e7%u00f6z%u00fcnen bir vitamin olup, antioksidan %u00f6zellikleri ile h%u00fccreleri serbest radikallerden korur ve cilt sa%u011fl%u0131%u011f%u0131n%u0131 iyile%u015ftirmektedir.S%u00fcperkritik ekstraksiyon s%u00fcreci %u015fu ad%u0131mlardan olu%u015fur:Haz%u0131rl%u0131k: %u0130lk ad%u0131mda, C ve E vitaminlerinin bulundu%u011fu spun patches offer a skin-compatible and comfortable application surface. The role of electrospinning technology in the production of transdermal patches is crucial for enhancing the efficacy and safety of these patches.In our study, PU nanotechnological transdermal patches loaded with C and E vitamins were obtained using electrospinning technology. The transdermal patches were analyzed using Field Emission Gun Scanning Electron Microscopy (FEGSEM). Nanotechnological transdermal patches for subcutaneous applications were produced.Materials and MethodsIn our study, C and E vitamins were obtained from patented plant extracts using the supercritical extraction technique.Production of C and E Vitamins Using Supercritical Extraction TechniqueThe supercritical extraction technique is a modern method used for the separation of plant and organic components. This technique is particularly preferred for obtaining C and E vitamins with high purity and efficiency. Supercritical extraction occurs in the supercritical phase of a fluid, where the fluid exhibits both gas and liquid properties. This method offers an effective solution for the production of sensitive components.Supercritical extraction is a separation technique that uses a fluid in its supercritical phase. The supercritical phase refers to a state where a fluid exhibits both liquid and gas properties under specific temperature and pressure conditions. In this phase, the fluid%u2019s solvation capacity increases significantly, which allows for more effective separation of organic components, particularly vitamins. Carbon dioxide (CO%u2082) is commonly used in supercritical extraction, as it is known to be an environmentally friendly solvent and is compatible with most vitamins. The supercritical phase of CO%u2082 has a high solvation capacity, facilitating the production of C and E vitamins with high purity.Vitamin C (ascorbic acid) is a water-soluble vitamin with strong antioxidant properties. It supports the immune system, improves skin health, and enhances iron absorption in the body. Vitamin E (tocopherols and tocotrienols) is a fat-soluble vitamin that protects cells from free radicals with its antioxidant properties and improves skin health.The supercritical extraction process involves the following steps:Preparation: The initial step involves preparing and appropriately sizing the plant materials containing C and E vitamins.Makale / Article